Pillar Guide

Men's Health Supplements — What the Evidence Actually Shows

Saw palmetto, zinc, beta-sitosterol, vitamin D, lycopene, testosterone boosters — the supplement aisle is full of claims. We break down what 30+ years of clinical research actually says, dosage ranges that show results, and which ones are mostly marketing.

Educational tracker only · ManCore does not sell supplements

Browse the Supplement Database

33 supplements men actually research, each with an evidence rating, mechanism, dosage, and safety notes — filter by category or search by name.

33 supplements

Saw Palmetto

BPH / urinary symptoms

Mixed Evidence

Beta-Sitosterol

BPH / urinary flow

Moderate Evidence

Pumpkin Seed Oil

BPH / urinary symptoms

Moderate Evidence

Zinc

Prostate tissue support / testosterone

Strong Evidence

Lycopene

Prostate cancer risk reduction

Moderate Evidence

Ashwagandha

Testosterone / stress / libido

Moderate Evidence

Tongkat Ali

Testosterone / libido

Moderate Evidence

Boron

Free testosterone / SHBG reduction

Moderate Evidence

DHEA

Hormone precursor support

Mixed Evidence

Fenugreek

Testosterone / libido

Moderate Evidence

Shilajit

Testosterone / energy / fertility

Preliminary Evidence

Maca Root

Libido

Moderate Evidence

Tribulus Terrestris

Libido (not testosterone)

Mixed Evidence

CoQ10

Sperm quality / fertility

Moderate Evidence

Omega-3 Fatty Acids

Hormonal & cardiovascular support

Moderate Evidence

Magnesium

Sleep / free testosterone

Moderate Evidence

Vitamin D

Hormonal support (in deficient men)

Moderate Evidence

Vitamin C

Antioxidant / sperm protection

Preliminary Evidence

Selenium

Prostate & fertility antioxidant support

Moderate Evidence

Creatine Monohydrate

Strength / muscle (not DHT, despite the myth)

Strong Evidence

NAC

Sperm quality / antioxidant

Moderate Evidence

Resveratrol

Antioxidant / vascular support

Preliminary Evidence

Black Seed Oil

Testosterone / metabolic support

Preliminary Evidence

Mucuna Pruriens

Testosterone / stress / mood

Moderate Evidence

Pine Pollen

Testosterone (weak evidence)

Preliminary Evidence

Grape Seed Extract

Antioxidant / vascular support

Preliminary Evidence

Alpha Lipoic Acid

Metabolic / nerve health

Preliminary Evidence

Melatonin

Sleep quality (indirect testosterone support)

Moderate Evidence

Berberine

Metabolic / insulin sensitivity

Strong Evidence

L-Arginine

Erectile function / blood flow

Moderate Evidence

L-Citrulline

Erectile function / blood flow

Moderate Evidence

Panax Ginseng

Erectile function

Moderate Evidence

Pycnogenol

Erectile function (often combined with L-arginine)

Preliminary Evidence

Why supplement research matters for men 40+

By age 50, more than half of men show some signs of an enlarged prostate (BPH), and supplement marketing aimed at this group is massive — and mostly unregulated. Some ingredients (saw palmetto, beta-sitosterol, zinc) have real clinical trial data behind them. Others are dosed far below the levels used in actual studies, or have no human trial evidence at all.

ManCore doesn't sell supplements — we help you log what you're already taking, the dose, and how your symptoms change over time, so you (and your urologist) can see what's actually working for your body, not just what the label promises.

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Reviewed by ManCore Editorial TeamLast reviewed: 2026-06-01

Research cited on this page

Every ingredient breakdown linked from this guide draws on peer-reviewed clinical research. Here are key studies referenced across our saw palmetto, beta-sitosterol, zinc/lycopene/selenium, and vitamin D coverage — each one linked to its PubMed listing.

Tacklind J, et al. Serenoa repens for benign prostatic hyperplasia (Cochrane Review) [PubMed ↗]
Barry MJ, et al. Saw palmetto for symptomatic BPH — JAMA [PubMed ↗]
Bent S, et al. Saw palmetto for benign prostatic hyperplasia — NEJM [PubMed ↗]
Wilt T, et al. Beta-sitosterols for BPH — British Journal of Urology [PubMed ↗]
Berges RR, et al. Randomised, placebo-controlled trial of beta-sitosterol in BPH — The Lancet [PubMed ↗]
Clark LC, et al. Selenium supplementation and cancer incidence — JAMA [PubMed ↗]
Giovannucci E, et al. Intake of carotenoids (lycopene) and prostate cancer risk — JNCI [PubMed ↗]
Lippman SM, et al. SELECT trial: vitamin E and selenium for prostate cancer prevention — JAMA [PubMed ↗]
Kenfield SA, et al. Vitamin D status and prostate outcomes — Journal of Clinical Oncology [PubMed ↗]
McVary KT, et al. AUA guideline on management of BPH — Journal of Urology [PubMed ↗]